Long non-coding RNAs in myelodysplastic syndromes: clinical relevance and implication in the pathogenesis

Long non-coding RNAs in myelodysplastic syndromes: clinical relevance and implication in the pathogenesis

Long non-coding RNAs (lncRNA) are defined as transcripts longer than 200 nucleotides that are not translated into protein. The aim of the project is to characterize expression, implication and clinical relevance of lncRNAs in myelodysplastic syndromes (MDS),  a group of diseases that affects normal blood cell production in the bone marrow. We will define MDS-specific lncRNA profiles and identify deregulated lncRNAs. The data will be correlated with clinical parameters to evaluate their diagnostic applicability. The project is lead by Dr. Dostálová Merkerová from the Institute of Hematology and Blood Transfusion. The main responsibility of the CTU team lies in integrated network analysis helping to clarify lncRNA function in the disease.

Researchers involved: Michaela Dostálová Merkerová (IBHT), Zdeněk Krejčík (IBHT), Jiří Kléma, Vladimír Kunc